Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers

Thomas P. Buters; Pieter W. Hameeteman; Iris M. E. Jansen; Floris C. van Hindevoort; Wouter ten Voorde; Edwin F. Florencia; Michelle Osse; Marieke L. de Kam; Hendrika W. Grievink; Mascha Schoonakker; Amit A. Patel; Simon Yona; Derek W. Gilroy; Erik Lubberts; Jeffrey Damman; Gary Feiss; Robert Rißmann; Manon A. A. Jansen; Jacobus Burggraaf; Matthijs Moerland

doi:10.1111/bcp.14999

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Abstract

Intradermal LPS administration in humans causes an acute, localized and transient inflammatory reaction that is well-tolerated by healthy volunteers. This may be a valuable inflammation model for evaluating the pharmacological activity of anti-inflammatory investigational compounds in proof of pharmacology studies.

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Buters et al. (2021) studied this question.

synapsesocial.com/papers/69dffb8c93e101b251e9c56a https://doi.org/10.1111/bcp.14999

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Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers

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Abstract

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Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers

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