Why the study?
Do cardiopulmonary exercise testing variables predict death, transplantation, hospitalization, and morbidity in Fontan patients?
Do cardiopulmonary exercise testing variables predict death, transplantation, hospitalization, and morbidity in Fontan patients?
Specific cardiopulmonary exercise testing variables, such as a decline in peak VO2 and exercise oscillatory ventilation, are strong predictors of adverse outcomes like death and transplantation in Fontan patients.
Specific CPET variables should guide risk stratification and transplant timing in Fontan patients; extends prognostic value beyond peak VO2 alone.
In Fontan patients, the best predictors of death and transplantation were a decline in peak VO₂, heart rate variables and exercise oscillatory ventilation. Peak VO₂ was not strongly predictive of mortality or hospitalisation in Fontan patients. Several variables were strong and independent predictors of hospitalisation and morbidity.
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Udholm et al. (2018) studied this question.