Reveals how metal ions enhance the activity of NEIL1 variants, suggesting implications for DNA repair mechanisms.
This study is the first report of the metal-dependent stimulation of compromised activities in a DNA glycosylase variant. The MD simulations suggest that Mg²⁺ stabilizes the surface loop dynamics in the T103A variant, with the effects of the T to A substitution and Mg²⁺ presence being transmitted over a distance greater than 26 Å to the NEIL1 active site.
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Zuckerman et al. (2026) studied this question.
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