The urinary Isoxanthopterin/pterin Ratio Reflects Mild Fasting Hyperglycemia in Obese Patients with Type 2 Diabetes Mellitus: An Exploratory Cross-sectional Study

Key Points

• This research aims to evaluate if urinary isoxanthopterin can serve as a marker for fasting hyperglycemia linked to xanthine oxidase activity in obese patients with type 2 diabetes.
• Conducted an exploratory cross-sectional study design.
• Measured urinary isoxanthopterin levels and fasting glucose in obese type 2 diabetes patients.
• Analyzed the relationship between urinary isoxanthopterin and fasting hyperglycemia.
• Identified a significant correlation between urinary isoxanthopterin levels and fasting hyperglycemia.
• The urinary isoxanthopterin/pterin ratio provided insights into the oxidative stress related to type 2 diabetes.
• Findings indicate potential implications for using urinary markers in diabetes management.