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Exploratory cross-sectional study explores a urinary marker for hyperglycemia in obese individuals with type 2 diabetes, suggesting a new diagnostic route.
Objective The exaggerated activation of xanthine oxidase (XO) provokes oxidative stress, a feature of type 2 diabetes mellitus (T2DM) and obesity. Because measuring the plasma XO activity is complicated, we tested whether urinary isoxanthopterin (IXP), the end product of pterin metabolism catalyzed by XO, could serve as an alternative marker.
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Chinen et al. (2026) studied this question.
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