Participants with NOTCH3 p.R544C variant reveal prognostic insights from SVD staging, suggesting clinical significance.
The NOTCH3-SVD staging system was developed to characterize NOTCH3-related small vessel disease (SVD), but it has not been validated in cohorts carrying a single pathogenic variant. We applied this system to Taiwanese individuals with the NOTCH3 p.R544C variant to evaluate its clinical relevance and prognostic value.
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Shen et al. (2026) studied this question.
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