Evaluates the antibacterial effects of arginine-loaded nanoparticles against Enterococcus faecalis, suggesting a new method for root canal disinfection.
Key Points
The aim is to evaluate the antibacterial efficacy of arginine-loaded mesoporous silica nanoparticles against E. faecalis.
Synthesize mesoporous silica nanoparticles and load with arginine.
Assess antibacterial activity through bacterial culture assays.
Evaluate effects on osteogenic differentiation in MC3T3-E1 cells.
Establish an E. faecalis-infected root canal model in extracted teeth.
Compare the efficacy of MSN@Arg with chlorhexidine and calcium hydroxide.
MSN@Arg exhibited sustained and stable release of arginine.
It inhibited E. faecalis in both planktonic and biofilm states.
MSN@Arg showed greater antibacterial efficacy than calcium hydroxide on days 3 and 7.
It was comparable to chlorhexidine on day 14 and slightly more effective on day 21.
MSNs demonstrated extensive distribution within dentinal tubules with high biocompatibility.