Beyond the Comfort Zone: Elevation, Temperature, Fatigue and Pain Perception

April 14, 2026Applied SciencesOpen Access

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Key Points

The aim is to evaluate how different environmental stressors and exertion influence pain perception in humans.
Used repeated-measures design with 45 participants
Conducted controlled sessions in a thermoclimatic chamber
Tested various conditions: baseline, altitude 4200 m, heat 42 °C, cold -10 °C, and exertion
Applied electrical stimuli to assess pain responses
Employed linear mixed-effects models for analysis
Heat exposure significantly increased sensory and pain thresholds compared to other conditions
Cold exposure yielded the highest tolerance thresholds
Altitude conditions consistently resulted in the lowest thresholds for pain sensitivity
Substantial within-subject differences were noted between thermal extremes
Opposing thermal effects on sensory/pain versus tolerance thresholds were identified

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Controlled lab sessions assess how environmental stressors impact pain perception in individuals, indicating important variations.

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Kryst et al. (2026) studied this question.

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