What question did this study set out to answer?

The aim is to develop ferulic and p-coumaric acid derivatives that inhibit EGFR and VEGFR2 for breast cancer treatment.

April 16, 2026Open Access

Ferulic and p -coumaric acid derivatives as dual EGFR-VEGFR2 inhibitors: design, semi-synthesis, and biological investigations

RERanza ElrayessSuez Canal University MNMohamed S. NafieSuez Canal University SASafwat A. AhmedSuez Canal University

Key Points

The aim is to develop ferulic and p-coumaric acid derivatives that inhibit EGFR and VEGFR2 for breast cancer treatment.
Designed ferulic and p-coumaric acid derivatives
Synthesized compounds using semi-synthesis
Evaluated cytotoxicity through in vitro and in vivo assays
Compounds exhibited potent cytotoxic effects on breast cancer cells
Induced apoptosis in tested breast cancer models
Demonstrated effective dual inhibition of EGFR and VEGFR2

Abstract

A series of ferulic and p -coumaric acid derivatives was designed and synthesized as dual EGFR/VEGFR2 inhibitors with potent cytotoxicity against breast cancer through apoptosis induction evaluated in vitro and in vivo approaches.

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Cite This Study

Elrayess et al. (Thu,) studied this question.

synapsesocial.com/papers/69e07c972f7e8953b7cbdb7a https://doi.org/https://doi.org/10.1039/d6ra01213b

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