What question did this study set out to answer?

To assess the impact of temporary mycophenolate mofetil discontinuation and reintroduction on long-term graft outcomes in pediatric kidney transplantation.

April 16, 2026Pediatric Nephrology0 citationsOpen Access

Temporary mycophenolate discontinuation and reintroduction in pediatric kidney transplantation: predictors and long-term outcomes

MTMoran Plonsky ToderTechnion – Israel Institute of Technology SPShirley PollackRambam Health Care Campus RTRami TibiRambam Health Care Campus

Key Points

To assess the impact of temporary mycophenolate mofetil discontinuation and reintroduction on long-term graft outcomes in pediatric kidney transplantation.
Analyzed a real-world cohort of pediatric kidney transplant recipients.
Monitored mycophenolate mofetil discontinuation and reintroduction closely.
Identified predictors of discontinuation, focusing on age.
Temporary MMF discontinuation was not linked to adverse long-term graft outcomes.
Younger age at transplantation correlated with higher MMF discontinuation likelihood.
Supports customized immunosuppression strategies for pediatric patients.

Abstract

In this real-world pediatric cohort, temporary MMF discontinuation, when clinically indicated, closely monitored, and followed by cautious reintroduction, was not associated with adverse long-term graft outcomes. Younger age at transplantation was associated with a higher likelihood of MMF discontinuation, supporting individualized immunosuppression strategies and proactive efforts to identify children at risk for viral-driven immunosuppression intolerance.

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