Circadian rest/activity rhythms and change in MRI‐derived brain volumes: Differences by age in a cognitively healthy sample

Marc A. Kaizi‐Lutu; Daniel D. Callow; Jill A. Rabinowitz; Brendan P. Lucey; Yang An; Mark N. Wu; Vadim Zipunnikov; Arnold Bakker; Christos Davatzikos; Eleanor M. Simonsick; Keenan A. Walker; Luigi Ferrucci; Susan M. Resnick; Adam P. Spira

doi:10.1002/alz.71190

April 1, 2026Alzheimer s & DementiaOpen Access

Circadian rest/activity rhythms and change in MRI‐derived brain volumes: Differences by age in a cognitively healthy sample

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Key Points

The aim is to explore the relationship between circadian rest/activity rhythms and changes in brain volumes, focusing on age variations.
Analyzed MRI-derived brain volumes of participants
Focused on medial temporal lobe and global brain volumes
Considered age as a variable in data interpretation
Circadian rest/activity rhythms were associated with increased medial temporal lobe and global brain volumes.
The strength of these associations varied across different age groups.

Implication

Research links circadian rhythms to brain volume changes in cognitively healthy individuals, suggesting age-related differences.

Abstract

Results link RARs with medial temporal lobe and global brain volumes and indicate that these associations may differ by age. Research is needed on the effects of RAR-focused interventions on brain health.

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Cite This Study

Kaizi‐Lutu et al. (2026) studied this question.

synapsesocial.com/papers/69e07cc02f7e8953b7cbdef4 https://doi.org/10.1002/alz.71190

View Full Paper

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Circadian rest/activity rhythms and change in MRI‐derived brain volumes: Differences by age in a cognitively healthy sample

Key Points

Implication

Abstract

Discussion

Cite This Study

Circadian rest/activity rhythms and change in MRI‐derived brain volumes: Differences by age in a cognitively healthy sample

Key Points

Implication

Abstract

Discussion

Cite This Study

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