Modulation of Iron-Induced Glucose Metabolic Reprogramming Alleviates Retinal Pigment Epithelial Cell Senescence

Zhenzhen Zhao; Qingjian Ou; Jincheng Zhu; Zixu He; Yanrong Yang; J Jiang; Q Wang; Yi Zhou; Ying Liu; Xiaoman Zhu; Tingting Cui; Yifan Liu; J F Xu; Furong Gao; Caixia Jin; Yì Wáng; Lixia Lu; Yanlong Bi; Guo-Tong Xu; J F Xu; H L Tian

doi:10.1167/iovs.67.4.30

Key Points

The study aims to explore how iron-induced changes in glucose metabolism affect retinal pigment epithelial cell aging.
Analyze glucose metabolic pathways in retinal pigment epithelial cells
Examine the effects of iron on glucose flux and ROS production
Evaluate mitochondrial health in relation to glucose reprogramming
Iron causes increased glucose metabolism linked to cell aging
Targeted modulation of glucose pathways reduces mitochondrial damage
Preventing glucose disruptions helps maintain retinal cell function

Implication

Observational study shows glucose metabolism alleviates retinal cell senescence, indicating a potential strategy for age-related degeneration.

Abstract

Glucose metabolic reprogramming mediates iron-induced RPE senescence, with transient glucose flux surge driving pathology via ROS-related mitochondrial damage. Targeting glucose metabolism may preserve mitochondria homeostasis and prevent RPE degeneration in age-related macular degeneration.

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Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/69e07d732f7e8953b7cbe631 https://doi.org/10.1167/iovs.67.4.30

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Modulation of Iron-Induced Glucose Metabolic Reprogramming Alleviates Retinal Pigment Epithelial Cell Senescence

Key Points

Implication

Abstract

Discussion

Cite This Study

Modulation of Iron-Induced Glucose Metabolic Reprogramming Alleviates Retinal Pigment Epithelial Cell Senescence

Key Points

Implication

Abstract

Discussion

Cite This Study

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