The aim is to identify PAICS as a key regulator involved in the epithelial-mesenchymal transition linked to breast cancer metastasis.
Conducted multi-omics analysis to examine molecular interactions
Evaluated PAICS expression levels in breast cancer samples
Analyzed immune microenvironment changes related to PAICS activity
PAICS is identified as a significant biomarker for breast cancer metastasis
Modulation of epithelial-mesenchymal transition is linked to PAICS
Alterations in the immune microenvironment are associated with PAICS expression
Abstract
PAICS acts as a biomarker that promotes breast cancer metastasis by modulating epithelial-mesenchymal transition and the immune microenvironment, offering potential for clinical translation.