PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
April 16, 2026Psychiatry and Clinical Neurosciences2 citations

Integrated transcriptomic and clinical analysis of autism spectrum disorder reveals structured heterogeneity and links Methyl‐CpG Binding Domain Protein 2 expression with symptom severity

View Full Paper
WYWasana YuwattanaCPChayanit PoolcharoenTSThanit Saeliw

Key Points

  • To investigate biological heterogeneity in autism spectrum disorder (ASD) through integrated transcriptomic and clinical analyses.
  • Conducted transcriptomic analyses to assess gene expression patterns in ASD
  • Stratified data to reveal molecular heterogeneity
  • Correlated symptoms severity with expression levels of specific proteins
  • Identified structured biological heterogeneity in ASD
  • Established a link between Methyl-CpG Binding Domain Protein 2 expression and the severity of symptoms

Abstract

Transcriptomic stratification reveals biologically structured heterogeneity in ASD that is only partially reflected in clinical presentation, supporting a multilayered framework integrating molecular and phenotypic dimensions.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Yuwattana et al. (2026) studied this question.

synapsesocial.com/papers/69e07dc72f7e8953b7cbeb8ehttps://doi.org/10.1111/pcn.70065
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Machine learning of clinical phenotypes facilitates autism screening and identifies novel subgroups with distinct transcriptomic profiles2025 · 13 citations
  2. 2Impact of innate immunity in a subset of children with autism spectrum disorders: a case control study2008 · 115 citations
  3. 3Calculating Sample Size Estimates for RNA Sequencing Data2013 · 357 citations
  4. 4Exaggerated translation causes synaptic and behavioural aberrations associated with autism2012 · 382 citations
  5. 5Impact of gene polymorphisms involved in the vitamin D metabolic pathway on the susceptibility to and severity of autism spectrum disorder2024 · 14 citations