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April 16, 20260 citationsOpen Access

Hierarchical Friction Memory Affects Dynamics of Fast-Folding Proteins

Hierarchical friction memory leads to subdiffusive configurational dynamics of fast-folding proteins

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Authors

AKAnton KlimekBDBenjamin A. DaltonLTLucas Tepper

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Overview

Investigates subdiffusive dynamics in fast-folding proteins, suggesting memory effects dominate over free-energy landscape effects.

Key Points

  • This research examines how friction memory influences the dynamics of fast-folding proteins, focusing on subdiffusion.
  • Analyzed the dynamics of fast-folding proteins using mean squared displacement (MSD) and mean first-passage-time (MFPT).
  • Developed a hierarchical multiexponential model for the friction memory kernel based on molecular dynamics simulations.
  • Compared effects of friction memory and free-energy landscape on protein folding dynamics.
  • Identified that friction memory significantly contributes to subdiffusion in MSD for short time scales.
  • Demonstrated that the free-energy landscape plays a lesser role in subdiffusion at longer time scales.
  • Showed that Markovian models fail to entirely capture protein folding dynamics, emphasizing the importance of memory effects.
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Cite This Study

Klimek et al. (2026) studied this question.

synapsesocial.com/papers/69e07e242f7e8953b7cbf21dhttps://doi.org/10.17169/refubium-51873
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