CNS tumor type prevalence according to age group: an analysis of 21,000 cases confirmed by methylation profiling, with a focus on adolescents and young adults

Adriana Fonseca; Leeor Yefet; Omkar Singh; Christopher Dampier; Karen Dazelle; Michelle Lam; Zied Abdullaev; Hye‐Jung Chung; Martha Quezado; Mark Raffeld; Jeffrey Gagan; Ina Lee; MacLean Nasrallah; Julie Bennett; Eric Bouffet; Dipak Poria; Pieter Wesseling; Martin van den Bent; Patrick Y Wen; Pascale Varlet; Arnault Tauziède-Espariat; Cristiane M. Ida; Gelareh Zadeh; Kenneth Aldape

doi:10.1093/neuonc/noag082

Key Points

To analyze the prevalence of CNS tumors using methylation profiling in different age groups, focusing on adolescents and young adults.
Conducted large-scale methylation profiling on 21,000 cases of CNS tumors
Classified tumor types and subclasses based on genomic alterations
Focused specifically on the adolescent and young adult age group
Identified unique classification patterns of CNS tumors in adolescents and young adults
Certain tumor types and subclasses were significantly enriched in this population
Findings provide a reference for understanding CNS tumor spectrum in AYAs

Implication

Large-scale analysis uncovers CNS tumor type prevalence in adolescents and young adults, suggesting important classification patterns.

Abstract

Large-scale methylation profiling revealed unique classification patterns of CNS tumors in AYAs, with specific tumor types, subclasses, and genomic alterations enriched in this population. These data may serve as a valuable reference resource for better understanding the spectrum of CNS tumors affecting AYA patients.

Discussion

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Cite This Study

Fonseca et al. (2026) studied this question.

synapsesocial.com/papers/69e07e582f7e8953b7cbf51a https://doi.org/10.1093/neuonc/noag082

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CNS tumor type prevalence according to age group: an analysis of 21,000 cases confirmed by methylation profiling, with a focus on adolescents and young adults

Key Points

Implication

Abstract

Discussion

Cite This Study

CNS tumor type prevalence according to age group: an analysis of 21,000 cases confirmed by methylation profiling, with a focus on adolescents and young adults

Key Points

Implication

Abstract

Discussion

Cite This Study

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