Compaction of co-amorphous griseofulvin/amino acid powders at elevated temperatures and their “in-tablet” stability

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This research aims to evaluate the compaction properties and stability of co-amorphous griseofulvin and amino acid powders at high temperatures.
Assessed the compaction behavior of co-amorphous griseofulvin/amino acid mixtures under elevated temperatures.
Evaluated flowability characteristics to ensure effective direct compression.
Monitored in-tablet stability to determine the viability for pharmaceutical applications.
Co-amorphous griseofulvin and amino acid mixtures showed promising compaction properties.
Adequate flowability was achieved, essential for direct tablet formation.
In-tablet stability indicates potential for practical pharmaceutical use.

Research demonstrates the stability of co-amorphous griseofulvin/amino acid tablets, indicating practical uses in pharmaceuticals.

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Partheniadis et al. (2026) studied this question.

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