August 13, 2007Archives of Neurology163 citations
View Full PaperInduction of Antigen-Specific Tolerance in Multiple Sclerosis After Immunization With DNA Encoding Myelin Basic Protein in a Randomized, Placebo-Controlled Phase 1/2 Trial
Structured PICO
Does BHT-3009 induce antigen-specific immune tolerance and reduce inflammatory lesions on brain MRI in patients with multiple sclerosis?
P
Population
Patients with Multiple Sclerosis (MS)
I
Intervention
BHT-3009 (DNA encoding myelin basic protein)
C
Comparator
Placebo
O
Outcome
Antigen-specific immune tolerance and reduction of inflammatory lesions on brain MRIsurrogate
In patients with multiple sclerosis, BHT-3009 is safe and induces antigen-specific immune tolerance with a reduction in inflammatory brain MRI lesions.
Abstract
In patients with MS, BHT-3009 is safe and induces antigen-specific immune tolerance with concordant reduction of inflammatory lesions on brain MRI.