EPRS plays a key role in pathological cardiac remodeling by controlling the translation of profibrotic genes in cardiac fibroblasts.
Our results indicate that EPRS preferentially controls translational activation of proline codon rich profibrotic genes in cardiac fibroblasts and augments pathological cardiac remodeling. Graphical Abstract: A graphical abstract is available for this article.
Wu et al. (Wed,) studied this question.
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