Effects of d-alanine Intake on Amino Acid Metabolism and Kidney Function in Healthy Adults: A Multicenter, Randomized Pilot Study

Megumi Oshima; Tadashi Toyama; Tatsuhiko Toyama; Yusuke Nakade; Toshiaki Tokumaru; Keisuke Sako; Sho Kajikawa; Daiki Hayashi; Hajime Sanada; Takahiro Yuasa; Akihiko Koshino; Keisuke Horikoshi; Taichiro Minami; Shunsuke Tsuge; Akira Tamai; Shiori Nakagawa; Ryo Nishioka; Takeshi Zoshima; Kiyoaki Ito; Shinji Kitajima; Ichiro Mizushima; Akinori Hara; Norihiko Sakai; Miho Shimizu; Masashi Mita; Yasunori Iwata; Takashi Wada

doi:10.1016/j.cdnut.2024.103787

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Abstract

d-alanine intake increased plasma and urine d-alanine levels and was well tolerated in participants with normal kidney function. These results will be useful in future trials investigating the effects of d-alanine intake on kidney disease progression in patients with chronic kidney disease.This trial was registered at the UMIN Clinical Trials Registry as UMIN000051466.

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Oshima et al. (2024) studied this question.

synapsesocial.com/papers/69e1c87d45c770d357ad3dcf https://doi.org/10.1016/j.cdnut.2024.103787

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Effects of d-alanine Intake on Amino Acid Metabolism and Kidney Function in Healthy Adults: A Multicenter, Randomized Pilot Study

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Abstract

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Effects of d-alanine Intake on Amino Acid Metabolism and Kidney Function in Healthy Adults: A Multicenter, Randomized Pilot Study

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Abstract

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