Ferulic acid promotes proliferation and angiogenesis of cerebral microvascular endothelial cells in Moyamoya disease via the SIRT1/HIF-1α/VEGF-A axis

Tao Gao; Ziqiang Liu; Li Wang; Liming Zhao; Chaoyue Li

doi:10.1016/j.brainresbull.2026.111886

April 13, 2026Brain Research BulletinOpen Access

Ferulic acid promotes proliferation and angiogenesis of cerebral microvascular endothelial cells in Moyamoya disease via the SIRT1/HIF-1α/VEGF-A axis

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Key Points

The aim is to investigate the effects of ferulic acid on endothelial cell proliferation and angiogenesis in the context of Moyamoya disease.
Examined the impact of ferulic acid on Bend.3 cerebral microvascular endothelial cells.
Evaluated oxidative stress and mitochondrial injury under conditions of oxygen-glucose deprivation (OGD).
Analyzed the activation of the SIRT1/HIF-1α/VEGF-A signaling pathway.
Ferulic acid reduced oxidative and mitochondrial damage in endothelial cells under OGD conditions.
Promoted angiogenesis-related responses in Bend.3 cells through the activation of the SIRT1/HIF-1α/VEGF-A axis.

Implication

Demonstrates that ferulic acid promotes angiogenesis in endothelial cells, suggesting a protective mechanism in Moyamoya disease.

Abstract

FA mitigated OGD-induced oxidative and mitochondrial injury in Bend.3 cells and promoted angiogenesis-related responses through activation of the SIRT1/HIF-1α/VEGF-A axis. These data support a SIRT1-dependent endothelial protective mechanism and provide a rationale for future studies evaluating FA in neurovascular-unit systems and in vivo models relevant to Moyamoya disease.

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Cite This Study

Gao et al. (2026) studied this question.

synapsesocial.com/papers/69e1cd6f5cdc762e9d856e7a https://doi.org/10.1016/j.brainresbull.2026.111886

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Ferulic acid promotes proliferation and angiogenesis of cerebral microvascular endothelial cells in Moyamoya disease via the SIRT1/HIF-1α/VEGF-A axis

Key Points

Implication

Abstract

Discussion

Cite This Study

Ferulic acid promotes proliferation and angiogenesis of cerebral microvascular endothelial cells in Moyamoya disease via the SIRT1/HIF-1α/VEGF-A axis

Key Points

Implication

Abstract

Discussion

Cite This Study

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