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April 10, 2026Archives of Pathology & Laboratory MedicineOpen Access

Mast Cell Activation Syndrome: Quantification of Mast Cells Across Conditions Reveals Limited Diagnostic Utility of Mast Cell Counts and Tryptase Depletion Index

Christoph Geisenberger Solveig Kuss Hans-Peter Horny Susanna Müller

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Key Points

This research investigates the effectiveness of mast cell counts and tryptase depletion index in diagnosing Mast Cell Activation Syndrome.
Assessment of mast cell counts in multiple conditions
Evaluation of diagnostic markers like CD25/CD30 and KIT mutations
Analysis of tryptase depletion index across different health conditions
Mast cell counts showed limited usefulness in diagnosis
Alternative markers such as CD25/CD30 and KIT mutations were more relevant.
Tryptase depletion index provided insufficient diagnostic information.

Implication

Quantification of mast cells shows limited diagnostic utility in various conditions, suggesting the need for alternative markers.

Abstract

While SM can be substantiated with markers such as CD25/CD30 or KIT mutations, counting mast cells appears of limited utility.

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Cite This Study

Geisenberger et al. (2026) studied this question.

synapsesocial.com/papers/69e1cd6f5cdc762e9d856fac https://doi.org/10.5858/arpa.2025-0007-oa

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