Computer-Aided Quantitative Image Analysis of Multiple Human Epidermal Growth Factor Receptor 2 Immunohistochemistry Assays in Breast Carcinoma

Mélissande Cossutta; Birgit Truumees; Alexandre Papine; Heidi Lykke Kristoffersen; Екатерина Татаринова; Lise Emanuelsen; Charles Homsy; Françoise Soussaline; Søren Nielsen

doi:10.5858/arpa.2025-0316-oa

April 13, 2026Archives of Pathology & Laboratory MedicineOpen Access

Computer-Aided Quantitative Image Analysis of Multiple Human Epidermal Growth Factor Receptor 2 Immunohistochemistry Assays in Breast Carcinoma

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Key Points

The aim is to evaluate the effectiveness of a quantitative image analysis method for HER2 scoring in breast carcinoma.
Utilized a computer-aided quantitative image analysis (QIA) method.
Assessed multiple immunohistochemistry (IHC) assays.
Compared HER2 classical overexpression and HER2-low levels.
The QIA method was accurate for HER2 scoring across different IHC assays.
It was agnostic to the assay type, ensuring consistent results.
The method can reliably distinguish between HER2-positive and HER2-low breast carcinomas.

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Implication

This analysis demonstrates accurate HER2 scoring in breast carcinoma, suggesting a reliable tool for pathologists.

Abstract

Our QIA method can be beneficial to use as a reliable HER2 scoring tool for HER2 classical overexpression and HER2-low in BCs. It was found to be agnostic and provided same accuracy irrespective of IHC assay applied.

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Cite This Study

Cossutta et al. (2026) studied this question.

synapsesocial.com/papers/69e1cdc45cdc762e9d8570c8 https://doi.org/10.5858/arpa.2025-0316-oa

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Computer-Aided Quantitative Image Analysis of Multiple Human Epidermal Growth Factor Receptor 2 Immunohistochemistry Assays in Breast Carcinoma

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Computer-Aided Quantitative Image Analysis of Multiple Human Epidermal Growth Factor Receptor 2 Immunohistochemistry Assays in Breast Carcinoma

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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