A screen identifies Alp1 and Nrt1 transporters as crucial for benzamidine uptake in fungi, suggesting new antifungal strategies.
Efflux pumps confer antifungal resistance. Benzamidine (BM) conjugates overcome resistance by enhancing intracellular accumulation, but their cellular uptake mechanism remains unclear. A screen of membrane transport protein mutants revealed that plasma membrane transporters Alp1 and Nrt1 are importers of BM conjugates and are essential for their antifungal activity.
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Jin et al. (2026) studied this question.
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