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Evaluating FABP5 as a Therapeutic Target for Pain Management | Synapse

April 17, 2026European Journal of Pain0 citations

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Evaluating FABP5 as a Therapeutic Target for Pain Management

WWWilliam Warren MOMyles OsbornPixelMill (United Kingdom)MKMartin KaczochaStony Brook School

Key Points

To assess the viability of FABP5 as a therapeutic target for managing pain through non-opioid approaches.
Reviewed existing literature on FABP5 and its role in pain modulation.
Evaluated efficacy in preclinical pain models.
Analyzed safety profiles of FABP5 inhibitors.
FABP5 inhibition demonstrated broad efficacy across various pain models.
Indicated favorable safety profiles compared to traditional analgesics.
Showed multiple mechanisms of action in pain relief.

Abstract

This review highlights fatty acid-binding protein 5 (FABP5) inhibition as a novel, non-opioid and non-steroidal analgesic strategy with multiple mechanisms of action, broad efficacy in preclinical pain models, and a favourable safety profile. FABP5 inhibition may offer promise for the treatment of complex painful conditions.

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Cite This Study

Warren et al. (Wed,) studied this question.

synapsesocial.com/papers/69e1ce065cdc762e9d85730c https://doi.org/https://doi.org/10.1002/ejp.70267