This review evaluates FABP5 inhibition as a novel analgesic strategy, suggesting its potential for complex pain conditions.
This review highlights fatty acid-binding protein 5 (FABP5) inhibition as a novel, non-opioid and non-steroidal analgesic strategy with multiple mechanisms of action, broad efficacy in preclinical pain models, and a favourable safety profile. FABP5 inhibition may offer promise for the treatment of complex painful conditions.
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Warren et al. (2026) studied this question.
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