MCC950‐Loaded M12‐Liposome Nanoparticles for Targeted Inhibition of NLRP3 Inflammasome in Sepsis‐Induced Muscle Atrophy

Yukun Liu; K Z Wang; Zhikai Xu; Xuan Zhao; Z L Li; Xiangjun Bai; Hao Zhu; Fangli Gao; Lei Zhu; Yuchang Wang

doi:10.1002/jcsm.70285

January 1, 2026Journal of Cachexia Sarcopenia and MuscleOpen Access

MCC950‐Loaded M12‐Liposome Nanoparticles for Targeted Inhibition of NLRP3 Inflammasome in Sepsis‐Induced Muscle Atrophy

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Key Points

This research aims to investigate the effectiveness of MCC950-loaded M12-liposome nanoparticles in targeting the NLRP3 inflammasome in muscle atrophy due to sepsis.
Developed MCC950-loaded M12-liposome nanoparticles for targeted delivery.
Administered nanoparticles to skeletal muscle.
Assessed inhibition of NLRP3 inflammasome activation and muscle atrophy.
M12-liposome@MCC950 nanoparticles significantly inhibited NLRP3 inflammasome activity.
Observed relief from muscle atrophy in sepsis models.
Reduced systemic toxicity compared to traditional delivery methods.

Implication

Nanoparticles deliver MCC950 to skeletal muscle, inhibiting NLRP3 inflammasome in sepsis, suggesting advanced treatment for muscle atrophy.

Abstract

M12-Liposome@MCC950 NPs provide a targeted and sustained-release strategy for delivering MCC950 to skeletal muscle, effectively inhibiting NLRP3 inflammasome activation and alleviating SIM. This approach enhances therapeutic efficacy while mitigating systemic toxicity, highlighting the potential of nanomedicine-based interventions for treating inflammation-related myopathies.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69e1cecc5cdc762e9d857d75 https://doi.org/10.1002/jcsm.70285

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MCC950‐Loaded M12‐Liposome Nanoparticles for Targeted Inhibition of NLRP3 Inflammasome in Sepsis‐Induced Muscle Atrophy

Key Points

Implication

Abstract

Discussion

Cite This Study

MCC950‐Loaded M12‐Liposome Nanoparticles for Targeted Inhibition of NLRP3 Inflammasome in Sepsis‐Induced Muscle Atrophy

Key Points

Implication

Abstract

Discussion

Cite This Study

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