Therapeutic drug monitoring and the role of pharmacokinetics/pharmacodynamics in optimizing beta-lactam antibiotic dosing for deep-seated infections: a systematic review

Key Points

• To assess the effectiveness of therapeutic drug monitoring (TDM) for optimizing beta-lactam antibiotic dosing in deep-seated infections.
• Conducted a systematic review of existing studies on TDM for beta-lactam antibiotics.
• Evaluated study quality and methodological approaches.
• Identified gaps in evidence and areas requiring further research.
• Current evidence on TDM for beta-lactams is limited and inconsistent.
• Identified significant methodological variances across studies.
• Proposes a need for well-designed clinical trials to determine TDM's effectiveness.