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Identifying novel susceptibility genes related to primary open-angle glaucoma (POAG) for improving diagnosis and treatment.

April 17, 2026Translational Vision Science & Technology0 citationsOpen Access

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Cross-Tissue Transcriptome-Wide Association Study and TWAS-FOCUS Fine-Mapping Reveal Novel Susceptibility Genes for Primary Open-Angle Glaucoma

ZPZheng PanCentral South University KLKe LiuCentral South University BJBo JiangCentral South University

Key Points

Identifying novel susceptibility genes related to primary open-angle glaucoma (POAG) for improving diagnosis and treatment.
Conducted a transcriptome-wide association study across different tissues
Utilized TWAS-FOCUS for fine-mapping genetic variants
Validated candidate genes through clinical data
Identified AFAP1 and FMNL2 as new susceptibility genes for POAG
Findings suggest these genes could enhance early diagnosis
Potential therapeutic targets for glaucoma management are proposed

Abstract

This study bridges basic genomics and clinical care by identifying and validating AFAP1 and FMNL2 as novel susceptibility genes for POAG, offering potential targets for early diagnosis and therapeutic intervention.

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View Full Paper

Cross-Tissue Transcriptome-Wide Association Study and TWAS-FOCUS Fine-Mapping Reveal Novel Susceptibility Genes for Primary Open-Angle Glaucoma

Key Points

Abstract

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