Key result
Circulating metabolites, including vitamin A and glutathione, are linked to RV systolic function in pulmonary hypertension.
Why the study?
Are specific metabolites and metabolic pathways associated with right ventricular systolic function in patients with pulmonary hypertension?
Observational
Are specific metabolites and metabolic pathways associated with right ventricular systolic function in patients with pulmonary hypertension?
This study identifies novel metabolic pathways, including vitamin A and glutathione metabolites, associated with right ventricular systolic function in pulmonary hypertension.
We provide a blueprint of metabolites and metabolic pathways associated with RV systolic function across the spectrum of PH. Novel links to vitamin A and glutathione metabolites were observed. We detected few metabolites that associated with RV systolic function differentially by group 1 PH status or degree of pulmonary vascular resistance elevation. Androgenic steroids may associate more strongly with RV systolic function in females compared with males.
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Chacon-Barahona et al. (2026) conducted an observational in Pulmonary Hypertension. Metabolites and metabolic pathways was evaluated on Right ventricular systolic function. Metabolites, including vitamin A and glutathione, were associated with right ventricular systolic function in pulmonary hypertension, with androgenic steroids showing stronger links in females.
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