Natural killer cells labeled with radionuclide-embedded double-layer gold nanoparticles conjugated to a mitochondrial localization sequence for PET/CT imaging and NK cell–based immunotherapy

Sang Bong Lee; Yong Hyun Jeon

doi:10.1080/17435889.2026.2659337

April 15, 2026Nanomedicine

Natural killer cells labeled with radionuclide-embedded double-layer gold nanoparticles conjugated to a mitochondrial localization sequence for PET/CT imaging and NK cell–based immunotherapy

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Key Points

This research aims to enhance PET/CT imaging techniques through the use of radionuclide-embedded gold nanoparticles labeled on natural killer cells.
Conjugation of gold nanoparticles with a mitochondrial localization sequence
Labeling of natural killer cells with radionuclide-embedded double-layer gold nanoparticles
Conducting PET/CT imaging to monitor NK cell dynamics
Stable labeling of NK cells was achieved
High-sensitivity imaging techniques improved real-time monitoring capabilities
The method supports preclinical validation for immunotherapy applications

Implication

This research demonstrates enhanced PET/CT imaging for NK cells, suggesting potential for immunotherapy applications.

Abstract

MLS-conjugated RI-DLGNPs enable stable labeling and high-sensitivity PET/CT imaging for real-time monitoring of NK cells, supporting further preclinical validation for immunotherapy applications.

Discussion

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Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/69e1cf985cdc762e9d85888e https://doi.org/10.1080/17435889.2026.2659337

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Natural killer cells labeled with radionuclide-embedded double-layer gold nanoparticles conjugated to a mitochondrial localization sequence for PET/CT imaging and NK cell–based immunotherapy

Key Points

Implication

Abstract

Discussion

Cite This Study

Natural killer cells labeled with radionuclide-embedded double-layer gold nanoparticles conjugated to a mitochondrial localization sequence for PET/CT imaging and NK cell–based immunotherapy

Key Points

Implication

Abstract

Discussion

Cite This Study

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