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April 15, 2026Arthritis Care & ResearchOpen Access

Real‐world Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Jay J. Patel Fauzia Hollangel MPH Caroline Packee Amita Kapoor B. Rovin Nathalie Costedoat‐Chalumeau Shivani Garg

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Key Points

This research aims to evaluate how monitoring hydroxychloroquine levels affects lupus outcomes in patients.
Conducted a prospective longitudinal cohort study.
Monitored hydroxychloroquine blood levels in patients with systemic lupus erythematosus.
Focused on patients with estimated glomerular filtration rate (eGFR) ≤75.
Improved control of systemic lupus erythematosus (SLE) was observed with blood level monitoring.
Patients with eGFR ≤75 benefited the most from hydroxychloroquine monitoring.

Implication

Prospective cohort study shows improved lupus control with hydroxychloroquine monitoring, indicating better treatment.

Abstract

HCQ blood level monitoring could improve SLE control, particularly in patients with eGFR ≤75, and enable optimal HCQ use.

Discussion

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Cite This Study

Patel et al. (2026) studied this question.

synapsesocial.com/papers/69e1cfb15cdc762e9d8589e4 https://doi.org/10.1002/acr.80059

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Defining Optimally Safe and Effective Blood Levels of Hydroxychloroquine in Lupus: An Important Step toward Precision Drug Monitoring2025 · 8 citations
2Defining Optimally Safe and Effective Blood Levels of Hydroxychloroquine in Lupus: An Important Step toward Precision Drug Monitoring2025
3POS0531 THERAPEUTIC HYDROXYCHLOROQUINE BLOOD LEVELS PREDICT LOWER MEAN FREQUENCY OF ACUTE CARE UTILIZATION IN LUPUS2024
4Optimizing Hydroxychloroquine Blood Levels and Long‐Term Hydroxychloroquine Intake Could Lower <scp>ASCVD</scp> Risk and Prevent Polypharmacy in Systemic Lupus ErythematosusCohort Study · 2026
5Effect of hydroxychloroquine blood concentration on the efficacy and ocular toxicity of systemic lupus erythematosus2024 · 14 citations

Therapeutic Hydroxychloroquine Blood Levels are Associated with Lower Lupus Hospitalizations and May Reduce Health Disparities in Lupus2024
902 Effect of cumulative hydroxychloroquine dose on prevention of damage progression and major adverse cardiovascular events in patients with systemic lupus erythematosus2024
Combining maintenance therapy with hydroxychloroquine increases LLDAS achievement rates in individuals with stable systemic lupus erythematosus2021
The association of gout flare resolution with physical activity and sleep: a prospective remote‐monitoring studyArthritis Care & Research · 2026
Generative AI in clinical practice: how should rheumatologists evaluate and monitor emerging tools?Arthritis Care & Research · 2026

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