Base Editing of TIGIT Reprograms CD155 Signaling in Natural Killer Cells to Enhance Cancer Immunotherapy Efficacy

Q: What does this research mean for the field?

Modifying a single base within the TIGIT gene in Natural Killer cells converts its inhibitory signaling into an activating axis, thereby enhancing antitumor immunity and improving cancer immunotherapy efficacy. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Cheng Fang; Guanglei Li; Min Han; Yue Wang; Wenxia Yu; Dan Hu; Jiaojiao Luo; 王立新; Wenwen Fan; Liling Wang; Tianhong Xu; Xingxu Huang; Chao Yao; Shiguo Zhu

doi:10.1158/0008-5472.can-25-0733

January 16, 2026Cancer Research

Base Editing of TIGIT Reprograms CD155 Signaling in Natural Killer Cells to Enhance Cancer Immunotherapy Efficacy

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Key Points

This research aims to explore how base editing the TIGIT gene affects NK cell signaling and antitumor responses.
Applied base editing technique to modify the TIGIT gene in NK cells.
Assessed changes in inhibitory and activating signaling pathways after modification.
Evaluated the antitumor immune response in treated NK cells.
Modified NK cells demonstrated enhanced antitumor immunity.
Signaling shifted from inhibitory to activating following TIGIT modification.
Base editing shows potential as a novel strategy for improving cancer immunotherapy.

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Implication

Base editing reprograms signaling in NK cells to boost cancer immunity, indicating a novel treatment approach.

Abstract

Modifying a single base within the TIGIT gene in NK cells switches inhibitory signaling to an activating axis that enhances antitumor immunity, supporting base editing of immune cells as an immunotherapeutic strategy.

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Cite This Study

Fang et al. (2026) studied this question.

synapsesocial.com/papers/69e1d0165cdc762e9d85914d https://doi.org/10.1158/0008-5472.can-25-0733

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Base Editing of TIGIT Reprograms CD155 Signaling in Natural Killer Cells to Enhance Cancer Immunotherapy Efficacy

Key Points

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Implication

Abstract

Discussion

Cite This Study

Base Editing of TIGIT Reprograms CD155 Signaling in Natural Killer Cells to Enhance Cancer Immunotherapy Efficacy

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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