FGFR2 is a Candidate Immune‐Associated Marker of Diabetic Foot Ulcer That Promotes Keratinocyte Function by Activating the PI3K/Akt and MAPK Pathways

Hailan Chen; Hongfei Sang; Y Q Shi; Jie Pan; C Zhang; F. H. Lei

doi:10.1155/mi/3260549

January 1, 2026Mediators of InflammationOpen Access

FGFR2 is a Candidate Immune‐Associated Marker of Diabetic Foot Ulcer That Promotes Keratinocyte Function by Activating the PI3K/Akt and MAPK Pathways

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Key Points

The aim is to investigate the role of FGFR2 in diabetic foot ulcers and its potential as a biomarker and treatment target.
Assessment of FGFR2 expression levels in diabetic foot ulcer samples.
Analysis of the activation of PI3K/Akt and MAPK pathways.
Evaluation of keratinocyte functions related to FGFR2 activation.
FGFR2 is found to be lowly expressed in diabetic foot ulcers.
Activation of the PI3K/Akt pathway by FGFR2 enhances keratinocyte function.
FGFR2 is identified as a potential diagnostic marker and therapeutic target for diabetic foot ulcers.

Implication

Demonstrates the role of FGFR2 in enhancing keratinocyte function in diabetic foot ulcers, suggesting therapeutic implications.

Abstract

FGFR2 is lowly expressed in DFU and can exert a protective effect by activating the PI3K/Akt pathway. It is a candidate diagnostic biomarker and potential therapeutic target for DFU.

Discussion

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69e1d0165cdc762e9d8592df https://doi.org/10.1155/mi/3260549

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FGFR2 is a Candidate Immune‐Associated Marker of Diabetic Foot Ulcer That Promotes Keratinocyte Function by Activating the PI3K/Akt and MAPK Pathways

Key Points

Implication

Abstract

Discussion

Cite This Study

FGFR2 is a Candidate Immune‐Associated Marker of Diabetic Foot Ulcer That Promotes Keratinocyte Function by Activating the PI3K/Akt and MAPK Pathways

Key Points

Implication

Abstract

Discussion

Cite This Study

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