Microglia membrane biomimetic platinum-based MOF-loaded quercetin nanodrug delivery system for the treatment of Alzheimer's disease

Key Points

• To develop a platinum-based drug delivery system using quercetin to treat Alzheimer's disease through targeting microglia.
• Designed a membrane biomimetic system using microglia to enhance delivery.
• Loaded platinum-based metal-organic frameworks (MOFs) with quercetin.
• Evaluated the effectiveness in reducing β-amyloid accumulation and microglial activation.
• Demonstrated decreased β-amyloid deposition in treatment groups.
• Observed a reduction in oxidative stress markers.
• Confirmed enhanced drug delivery efficiency to microglial cells.