Why the study?
Does stimulating glucose oxidation via targeting PDH or MCD decrease infarct size in models of acute myocardial infarction and reperfusion injury?
Does stimulating glucose oxidation via targeting PDH or MCD decrease infarct size in models of acute myocardial infarction and reperfusion injury?
Optimizing myocardial metabolism by stimulating glucose oxidation reduces infarct size, representing a potential novel therapeutic approach for ischemic heart disease.
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May limit infarct size in animal AMI models; leaves open translation of PDH/MCD targeting to clinical reperfusion therapy.
Ussher et al. (2012) studied this question.
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