Selective Decontamination of the Digestive Tract in Adult Mechanically Ventilated Patients — An Updated Systematic Review with Bayesian Meta-Analysis

Q: What does this research mean for the field?

Selective decontamination of the digestive tract (SDD) is associated with a reduced risk of in-hospital death compared to standard care in mechanically ventilated adults in the ICU. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Naomi Hammond; Anthony Devaux; Ruan Vlok; Derick Adigbli; Brian H. Cuthbertson; Simon R. Finfer; Tessa Garside; Qiang Li; Sajeev Mahendran; Sharon Micallef; Srinivas Murthy; John Myburgh; Louise Rose; Ian Seppelt; Balasubramanian Venkatesh; Anthony Delaney

doi:10.1056/evidoa2500264

April 15, 2026NEJM Evidence

Selective Decontamination of the Digestive Tract in Adult Mechanically Ventilated Patients — An Updated Systematic Review with Bayesian Meta-Analysis

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Key Points

This review aims to evaluate the effect of selective decontamination of the digestive tract on reducing in-hospital mortality in mechanically ventilated adults.
Conducted a systematic review of existing literature on SDD in ICU patients.
Performed a Bayesian meta-analysis to synthesize data and assess mortality outcomes.
Compared SDD outcomes against standard care protocols.
Findings indicate a high probability of reduced in-hospital death associated with SDD.
Statistical analysis supports stronger effects of SDD compared to standard care.

Implication

Systematic review demonstrates reduced in-hospital death risk in adults with SDD, suggesting significant clinical benefits.

Abstract

There is a high probability that in mechanically ventilated adults in the ICU, SDD, compared to standard care, is associated with a reduction in the risk of in-hospital death.

Discussion

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Cite This Study

Hammond et al. (2026) studied this question.

synapsesocial.com/papers/69e31ec840886becb653e636 https://doi.org/10.1056/evidoa2500264

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Selective Decontamination of the Digestive Tract in Adult Mechanically Ventilated Patients — An Updated Systematic Review with Bayesian Meta-Analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

Selective Decontamination of the Digestive Tract in Adult Mechanically Ventilated Patients — An Updated Systematic Review with Bayesian Meta-Analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

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