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The study aims to develop a highly selective JAK2 inhibitor for more effective treatment of myeloproliferative neoplasms.

Discovery of a highly selective JAK2 inhibitor with a furopyrimidine scaffold

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Discovery of a selective JAK2 inhibitor in myeloproliferative neoplasms, suggesting potential for targeted therapy.

The study aims to develop a highly selective JAK2 inhibitor for more effective treatment of myeloproliferative neoplasms.
Synthesis of furopyrimidine derivatives
Biochemical assays to evaluate selectivity
Structural optimization of JAK2 inhibitors
Docking studies for selectivity enhancement
Compound 14 shows approximately 10-fold selectivity for JAK2 over JAK1
Negligible inhibition of JAK3 and TYK2
New furopyrimidine derivatives identified as potential JAK inhibitors
Docking studies suggest terminal heteroatoms enhance selectivity

김민기 et al. (2026) studied this question.

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