What question did this study set out to answer?

To compare central and peripheral airway features in bronchiolitis obliterans (BO) and chronic obstructive pulmonary disease (COPD).

April 18, 2026BMC Pulmonary Medicine0 citationsOpen Access

Distinct central and peripheral airway features in bronchiolitis obliterans and COPD: an observational study

MKMariko KogoKyoto University NTNaoya TanabeKyoto University HMHisako MatsumotoKyoto University

Puntos clave

To compare central and peripheral airway features in bronchiolitis obliterans (BO) and chronic obstructive pulmonary disease (COPD).
Measured central airway volume and peripheral airway epithelial erosion in patients with BO and COPD.
Analyzed cell types including FOXJ1-positive and PAS-positive cells.
Compared lung function between the two groups.
Central airway volume and peripheral airway epithelial erosion were significantly greater in BO than in COPD.
Fewer FOXJ1-positive and PAS-positive cells were noted in BO despite similar lung function to COPD.
Key features of BO include central airway dilation and peripheral airway obstruction related to epithelial changes.

Resumen

Central airway volume and peripheral airway epithelial erosion were greater, with fewer FOXJ1-positive and PAS-positive cells in BO than COPD, despite similar lung function. Central airway dilation and peripheral airway obstruction associated with epithelial erosion and ciliated cell reduction may be key pathological features of BO.

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