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April 18, 2026Animal Bioscience0 citationsOpen Access

SIRT1 plays a critical role in maintaining the viability of Yak Sertoli cells by regulating mitochondrial biogenesis via activating the PGC-1α-NRF-1-TFAM pathway

DLDongju LiuXDXiaodong DongHZHuai Zhang

Key Points

  • The study aims to explore SIRT1's regulatory role in yak Sertoli cells and its impact on mitochondrial functions.
  • Investigated the role of SIRT1 in yak Sertoli cells
  • Examined the PGC-1α-NRF-1-TFAM pathway
  • Performed assays to assess cell viability and mitochondrial function
  • SIRT1 positively regulates mitochondrial biogenesis in Sertoli cells
  • Activation of the PGC-1α-NRF-1-TFAM pathway was observed
  • Enhanced viability of yak Sertoli cells was linked to SIRT1 activity

Abstract

The present study preliminarily elucidates the regulatory role and mechanism of SIRT1 in yak Sertoli cells, providing fundamental data and new insights for further research on the function of SIRT1 in reproductive regulation in yaks.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69e31f7340886becb653ea77https://doi.org/10.5713/ab.251005
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