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April 15, 2026Lasers in Surgery and Medicine

Pulsed 830‐nm Laser Irradiation Modulates Aδ‐ and C‐Fiber–Mediated Pain Thresholds in Healthy Adults: A Randomized, Sham‐Controlled Trial

Nobuyuki Takeuchi Masanao Matsumoto Masaya Tabei

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Key Points

This research aims to determine the effect of pulsed 830-nm laser irradiation on pain thresholds mediated by Aδ and C-fibers in healthy individuals.
Involved healthy adults as participants.
Applied pulsed 830-nm laser irradiation and compared effects with a sham treatment.
Assessed pain thresholds through standardized testing.
Laser irradiation significantly modulated pain thresholds compared to sham treatment.
Observed alterations in pain sensitivity related to Aδ and C-fiber activity.

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Implication

Examines how laser irradiation affects pain sensitivity in healthy individuals, indicating possible therapeutic uses.

Abstract

University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR), UMIN000056285.

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Cite This Study

Takeuchi et al. (2026) studied this question.

synapsesocial.com/papers/69e31f9e40886becb653ed33 https://doi.org/10.1002/lsm.70138

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Comment on “Pulsed 830‐nm Laser Irradiation Modulates Ad‐ and C‐Fiber–Mediated Pain Thresholds in Healthy Adults: A Randomized, Sham‐Controlled Trial”Original Research · 2026
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3Effect of Low-Intensity Transcranial Focused Ultrasound Stimulation on Neuropathic Pain: Protocol for a Randomized, Single-Blind, Placebo-Controlled, 3-Arm, Parallel-Group TrialClinical Trial · 2026
4Subperception dorsal root ganglion stimulation versus sham stimulation in established responders: a randomized, double-blind crossover clinical trialRCT · 2026
5Transcutaneous Pulsed Radiofrequency in Chronic Pain: A Systematic Review of Randomized Controlled TrialsSystematic Review · 2026

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