Immune-related pneumonitis: A retrospective analysis of corticosteroid requirements and the role of hydroxychloroquine in melanoma patients

Tanja Patricia Eicher; Lisa Hofer; Joanna Mangana; R Dummer; Lukas Kraehenbuehl

doi:10.1016/j.ejcskn.2026.101142

April 1, 2026EJC Skin CancerOpen Access

Immune-related pneumonitis: A retrospective analysis of corticosteroid requirements and the role of hydroxychloroquine in melanoma patients

View Full Paper

Ask AI

Bookmark

Share

Key Points

This study aimed to evaluate the role of hydroxychloroquine as an adjunct treatment in the management of immune-related pneumonitis in melanoma patients receiving immune checkpoint blockade.
Retrospective cohort study at University Hospital Zurich
Included adult metastatic melanoma patients treated with immune checkpoint blockade
Patients developed CTCAE grade 2 immune-related pneumonitis and were stratified by hydroxychloroquine exposure
Evaluated corticosteroid dosages and duration of therapy as primary and secondary outcomes
10 patients received hydroxychloroquine, while 36 did not
Hydroxychloroquine-treated patients had higher cumulative corticosteroid doses (median 4514 mg vs. 1627 mg) and longer therapy duration (131 days vs. 85 days) with no statistical significance
Average daily corticosteroid dose reduced significantly following hydroxychloroquine initiation
Two hydroxychloroquine-treated patients resolved pneumonitis without corticosteroids or further treatments

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Implication

Retrospective analysis evaluates hydroxychloroquine's role in corticosteroid management for melanoma patients with pneumonitis, suggesting potential benefits.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Eicher et al. (2026) studied this question.

synapsesocial.com/papers/69e31ff140886becb653f088 https://doi.org/10.1016/j.ejcskn.2026.101142

View Full Paper

Ask AI

Bookmark

Share

Immune-related pneumonitis: A retrospective analysis of corticosteroid requirements and the role of hydroxychloroquine in melanoma patients

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Immune-related pneumonitis: A retrospective analysis of corticosteroid requirements and the role of hydroxychloroquine in melanoma patients

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Keep reading

Keep reading