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Reveals that keratinocytes enhance humoral immunity through immune signaling pathways.
The skin is a highly organized immune organ in which resident non-immune cells cooperate with immune cells to maintain host defense and shape systemic adaptive immunity. A recent study revealed that a keratinocyte-intrinsic farnesyl pyrophosphate-transient receptor potential vanilloid 3 pathway transforms epidermal stress into interleukin-6- and chemokine-dependent signals that promote dendritic cell migration, T follicular helper-cell expansion and germinal center activity, thereby amplifying humoral immunity and autoimmunity.
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Guo et al. (2026) studied this question.
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