PulseTrendingJournal ClubResearchersJournalsExplore
Instagram
HomeTrendingJournal ClubExplore
Synapse
⌘+K
Synapse
April 18, 2026Neuroendocrinology

Stress-induced activation of orexin-A neurons in the lateral hypothalamus is similar in prepubertal and adult male and female rats despite age-dependent differences in hormonal stress reactivity

View Full Paper
Ask AI
Bookmark
Share

Authors

CSChelsea A. SeidelSCSofia CruzJOJuliet Dayana Pérez Ortiz

Discussion

Loading...

Member takes

Overview

Research reveals similar activation of orexin-A neurons in males and females, despite hormonal stress reactivity differences during development.

Key Points

  • This research aims to investigate how stress affects orexin-A neurons in prepubertal and adult rats and to explore hormonal stress responses across development.
  • Examined hormonal stress responses in prepubertal and adult rats
  • Counted activated orexin-A neurons by co-labeling with c-Fos
  • Quantified immunoreactive orexin-A neurons in different developmental stages of both sexes
  • Prolonged stress-induced hormonal responses in prepubertal males and females compared to adults
  • No developmental differences in the number of orexin-A neurons or their activation levels across sexes
  • Orexin-A neurons show consistent sensitivity to stressors prior to puberty

Cite This Study

Seidel et al. (2026) studied this question.

synapsesocial.com/papers/69e3215140886becb65407d3https://doi.org/10.1159/000552033
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sex-Specific Effects of Neonatal Stress on Brainstem Expression of Orexin1-Receptors2024
  2. 2The impact of pubertal stress and adult hormone exposure on the transcriptome of the developing hypothalamus2024 · 2 citations
  3. 3Astrocyte glucocorticoid receptors mediate sex-specific changes in activity following stress2024 · 6 citations
  4. 4Acute Stress Affects the Relaxin/Insulin‐Like Family Peptide Receptor 3 mRNA Expression in Brain of Pubertal Male Wistar Rats2024 · 1 citations
  5. 5EXPERIMENTAL STUDY: YOUTH COMPARED TO THE EXPERIENCE OF ADULTHOOD IN TERMS OF FEATURES OF STRESS RESPONSE2025