Hypertonic saline is a strong sterile solution of salt water that can be inhaled as a nebulized medication for people with cystic fibrosis (CF). To examine how it should be applied clinically, it is worth considering the mechanisms by which it affects the disease process, and which signs, symptoms and other clinical outcomes it influences. Finally, it is worth considering how the effect is influenced by the dose received, and whether this should influence how it is applied in clinical practice. This paper will review this information and relate it to the clinical application of hypertonic saline.
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Elkins et al. (2011) studied this question.
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