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Uncovers mediating effects of metabolic acidosis and fluid balance on mortality in critically ill patients with AKI, suggesting improved management could enhance outcomes.
Serum bicarbonate levels and fluid balance mediate approximately 40% of the mortality risk attributable to AKI. KRT is beneficial for AKI-associated mortality. Despite controversial results regarding the benefit of bicarbonate administration in AKI, the focus should remain on how managing metabolic acidosis-possibly beyond simple bicarbonate replacement-in combination with improved fluid balance management can enhance outcomes in critically ill patients with AKI.
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Macedo et al. (2026) studied this question.
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