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April 19, 2026Frontiers in Bioengineering and BiotechnologyOpen Access

Revisiting MSC heterogeneity: significance of the CD73+CD39+CD146+ perivascular subset in bone marrow

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Authors

RRRamya Lakshmi RajendranKyungpook National UniversityAMAtharva A. MahajanUniversity of MysoreBAByeong-Cheol AhnKyungpook National University Hospital

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Implication

This opinion identifies a unique CD73+CD39+CD146+ MSC subset enhancing HSC co-culture in bone marrow, suggesting its role in immune modulation.

Key Points

  • To explore the functional significance of the CD73+CD39+CD146+ mesenchymal stem cell subset in bone marrow.
  • Isolation of CD73+CD39+CD146+ MSCs using high-purity sorting techniques
  • Immunofluorescence to confirm perivascular localization
  • Functional assays to demonstrate self-renewal and adenosine production
  • CD73+CD39+CD146+ subset shows superior adenosine production (21.6 pmol/µL) compared to unsorted cells (16.4 pmol/µL)
  • Rare detection of the subset in mobilized blood indicates potential for enhanced transplant readiness
  • Substantially lower CD146 expression following dual mobilization with CXCR4 antagonist suggests altered adhesion dynamics

Cite This Study

Rajendran et al. (2026) studied this question.

synapsesocial.com/papers/69e470a4010ef96374d8d8d4https://doi.org/10.3389/fbioe.2026.1810362
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