Integrated computational and biological assessment of novel piperazine and piperidine-substituted 1,2,4-oxadiazoles for lung cancer therapy

Key Points

• The aim is to evaluate the potential of novel 1,2,4-oxadiazole derivatives for lung cancer treatment.
• Synthesize piperazine and piperidine-substituted 1,2,4-oxadiazoles
• Conduct molecular modeling to predict interactions with EGFR
• Assess antiproliferative activity through biological assays
• The 1,2,4-oxadiazole derivatives exhibited moderate antiproliferative effects
• Molecular modeling suggests potential interaction with the EGFR pathway
• Further optimization of these compounds is required for improved efficacy