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April 16, 2026iScienceOpen Access

Effect of opioid sparing anesthesia with esketamine on PONV in laparoscopic sleeve gastrectomy randomized trial

Kai-Rui Shi Min Zhao Ke Liu Dapeng Yu Bing-Yuan Zhang Hua Hong Lin Jiang Chun Yang

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Key Points

To evaluate the impact of opioid sparing anesthesia using esketamine on postoperative nausea and vomiting (PONV) during laparoscopic sleeve gastrectomy.
Conducted a randomized trial comparing two groups: one using esketamine and opioid sparing anesthesia, and one with standard anesthesia protocols.
Analyzed median consumption of sufentanil between groups (OSA and control).
Observed and recorded the incidence of PONV post-surgery.
Corrected median total consumption of sufentanil for the OSA group is 78 (IQR: 65-90) and 168 for the control group.
No changes affect data analysis or article conclusions despite table correction.

Implication

Randomized trial examines opioid sparing anesthesia's effect on PONV in laparoscopic sleeve gastrectomy, suggesting promising implications.

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Cite This Study

Shi et al. (2026) studied this question.

synapsesocial.com/papers/69e470a4010ef96374d8d99a https://doi.org/10.1016/j.isci.2026.114802

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Effect of Opioid Sparing Anaesthesia with Esketamine on PONV in Laparoscopic Sleeve Gastrectomy Randomized Trial2025 · 3 citations
2Balanced opioid-free anesthesia with lidocaine and esketamine versus balanced anesthesia with sufentanil for gynecological endoscopic surgery: a randomized controlled trial2024 · 23 citations
3Esketamine-led opioid-free anaesthesia reduces postoperative pulmonary complications in bariatric surgery patients: a prospective randomized controlled trialRCT · 2026 · 1 citations
4Opioid-sparing anaesthesia protocol on gastrointestinal function after benign gynaecological laparoscopic surgery: a prospective randomized controlled double-blind studyRCT · 2023
5Opioid‐Free Anesthesia With Erector Spinae Plane Block Versus <scp>IV</scp> Lidocaine for Laparoscopic Sleeve Gastrectomy: A Randomized Controlled TrialRCT · 2026

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The hemodynamic effects of esketamine-based opioid-free anesthesia in laparoscopic hepatectomy: a randomized clinical trial2025
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Effect of subanesthetic dose of esketamine on postoperative pain in elderly patients undergoing laparoscopic gastrointestinal tumor Surgery:A prospective, double-blind, randomized controlled trial2024

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