The Diagnostic Utility of Ultrasound in Myxofibrosarcoma: Insights From a Multimodal Imaging Case Study

Introduction Myxofibrosarcoma (MFS) is a malignant soft tissue sarcoma, representing less than 1% of all adult malignancies (Xiao et al. in Frontiers in Oncology . 2024). MFS often arises in extremities, especially the lower limbs, and is less common in the torso or head and neck. Clinically, this can present as a painless mass with slow rates of growth but often demonstrates a high propensity for infiltration and recurrence. MFS is characterised by pleomorphic spindle cells with a myxoid stroma and often demonstrates variable histological architectures and unique imaging signs (Vanni et al. The Adv Med Oncol . 2022). We describe a case that demonstrates the benefits of multi-modality imaging when investigating complex soft tissue lesions, underscoring the utility of ultrasound in characterising malignant sarcomas, enabling prompt referral and management. Publication History Received: 30 December 2025 Accepted after revision: 03 March 2026 Article published online: 16 April 2026 © 2026. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/). Georg Thieme Verlag KG Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany Bibliographical Record Neil Limaye, Hannah Masraf, Henry Conchie, Adrian Lim. The Diagnostic Utility of Ultrasound in Myxofibrosarcoma: Insights From a Multimodal Imaging Case Study. Ultrasound Int Open 2026; 12: a28263276. DOI: 10.1055/a-2826-3276