Five-Year Follow-up of a Multicenter Randomized Controlled Trial Comparing an Aragonite-Based Scaffold With Microfracture and Debridement for Chondral and Osteochondral Knee Lesions

Nir Altschuler; Kenneth R. Zaslav; Berardo Di Matteo; Seth L. Sherman; Andreas H. Gomoll; Scott Hacker; Peter Verdonk; Oliver Dulić; Jenel M. Patrascu; Andrew Levy; Dror Robinson; Elizaveta Kon

doi:10.1177/03635465261437781

April 16, 2026The American Journal of Sports Medicine

Five-Year Follow-up of a Multicenter Randomized Controlled Trial Comparing an Aragonite-Based Scaffold With Microfracture and Debridement for Chondral and Osteochondral Knee Lesions

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Key Points

This research aims to evaluate the long-term effectiveness of an aragonite-based scaffold compared to standard surgical options for knee lesions.
Conducted as a multicenter randomized controlled trial
Evaluated patients with chondral and osteochondral knee lesions
Followed participants for five years post-intervention
Aragonite-based scaffold demonstrated superior clinical outcomes compared to SSOC
Results confirmed safety of the scaffold
Improvements noted in patients with mild to moderate osteoarthritis over five years

Implication

Multicenter randomized trial shows aragonite-based scaffold improves outcomes in osteoarthritis, indicating its potential benefit.

Abstract

The results confirmed that the aragonite-based scaffold is both safe and superior to SSOC in improving clinical outcomes at up to 5 years' evaluation, as well as in patients with mild to moderate OA.

Discussion

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Cite This Study

Altschuler et al. (2026) studied this question.

synapsesocial.com/papers/69e47193010ef96374d8df28 https://doi.org/10.1177/03635465261437781

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Five-Year Follow-up of a Multicenter Randomized Controlled Trial Comparing an Aragonite-Based Scaffold With Microfracture and Debridement for Chondral and Osteochondral Knee Lesions

Key Points

Implication

Abstract

Discussion

Cite This Study

Five-Year Follow-up of a Multicenter Randomized Controlled Trial Comparing an Aragonite-Based Scaffold With Microfracture and Debridement for Chondral and Osteochondral Knee Lesions

Key Points

Implication

Abstract

Discussion

Cite This Study

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