Nodular secondary syphilis in a patient who was immunocompetent: a sporotrichoid masquerader with synchronous primary lesion

Jacopo Tartaglia; Francesco Fortarezza; Monica Ponzano; A P Dei Tos; Mauro ALAIBAC

doi:10.1093/skinhd/vzag026

March 4, 2026Skin Health and DiseaseOpen Access

Nodular secondary syphilis in a patient who was immunocompetent: a sporotrichoid masquerader with synchronous primary lesion

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Key Points

To present a rare case of nodular secondary syphilis that mimicked other dermatological conditions.
Described clinical presentation including concurrent lesions
Used dermoscopy and histology for initial diagnosis
Confirmed diagnosis with serology and Warthin–Starry staining
Identified concurrent chancre and sporotrichoid nodules
Histological examination raised suspicion for pseudolymphoma
Diagnosis of secondary syphilis confirmed through serological tests

Implication

Case report reveals concurrent chancre and sporotrichoid nodules in an immunocompetent man, suggesting diagnostic challenges.

Abstract

We report a case of nodular secondary syphilis in an immunocompetent man presenting with concurrent chancre, macular rash and sporotrichoid nodules. Dermoscopy and histology raised suspicion for pseudolymphoma, but serology and Warthin–Starry staining confirmed the diagnosis.

Discussion

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Cite This Study

Tartaglia et al. (2026) studied this question.

synapsesocial.com/papers/69e471c5010ef96374d8e007 https://doi.org/10.1093/skinhd/vzag026

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Nodular secondary syphilis in a patient who was immunocompetent: a sporotrichoid masquerader with synchronous primary lesion

Key Points

Implication

Abstract

Discussion

Cite This Study

Nodular secondary syphilis in a patient who was immunocompetent: a sporotrichoid masquerader with synchronous primary lesion

Key Points

Implication

Abstract

Discussion

Cite This Study

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