What question did this study set out to answer?

To present a rare case of nodular secondary syphilis that mimicked other dermatological conditions.

April 19, 2026Open Access

Nodular secondary syphilis in a patient who was immunocompetent: a sporotrichoid masquerader with synchronous primary lesion

JTJacopo TartagliaUniversity of Padua FFFrancesco FortarezzaUniversity of Padua MPMonica PonzanoUniversity of Padua

Key Points

To present a rare case of nodular secondary syphilis that mimicked other dermatological conditions.
Described clinical presentation including concurrent lesions
Used dermoscopy and histology for initial diagnosis
Confirmed diagnosis with serology and Warthin–Starry staining
Identified concurrent chancre and sporotrichoid nodules
Histological examination raised suspicion for pseudolymphoma
Diagnosis of secondary syphilis confirmed through serological tests

Abstract

We report a case of nodular secondary syphilis in an immunocompetent man presenting with concurrent chancre, macular rash and sporotrichoid nodules. Dermoscopy and histology raised suspicion for pseudolymphoma, but serology and Warthin–Starry staining confirmed the diagnosis.

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